In vivo cytogenetic analysis of shale-derived oils and process waters

Technical Report · Tue Sep 01 04:00:00 EDT 1981

OSTI ID:5875914

Meyne, J; Deaven, L L

The frequencies of chromosomal aberrations induced by intraperitoneal injection of female CD-1 mice with shale-derived oils and oil shale process waters were investigated. Exposure to a crude shale oil from a vertical, above-ground retort process induced a dose-related increase in the frequency of aberrations observed. A hydrotreated sample of this crude shale oil demonstrated a similar pattern of aberration induction, but at lower frequencies. A crude shale oil from a modified vertical in situ retort induced the highest frequency of aberrations at the lowest dose tested and elevated, but lower frequencies at the middle and high doses. Process waters from above-ground, modified vertical in situ, and modified horizontal in situ retort processes each induced slightly increased frequencies of aberrations, but the results were not dose related.

• Research Organization: Los Alamos National Lab., NM (USA)
• DOE Contract Number: W-7405-ENG-36
• OSTI ID: 5875914
• Report Number(s): LA-9001-MS; ON: DE82002474
• Country of Publication: United States
• Language: English

Related Subjects

04 OIL SHALES AND TAR SANDS
040700 -- Oil Shales & Tar Sands-- Health & Safety
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
CHROMOSOMAL ABERRATIONS
DATA
DOSE-RESPONSE RELATIONSHIPS
ENERGY SOURCES
EXPERIMENTAL DATA
FEMALES
FOSSIL FUELS
FUELS
INFORMATION
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
MAMMALS
MICE
MINERAL OILS
MUTATION FREQUENCY
MUTATIONS
NUMERICAL DATA
OILS
ORGANIC COMPOUNDS
OTHER ORGANIC COMPOUNDS
RODENTS
SHALE OIL
VERTEBRATES