Clastogenic effects of transplacental exposure of mouse embryos to nitrogen mustard of cyclophosphamide
Journal Article
·
· Teratog., Carcinog., Mutagen.; (United States)
Embryos from day 12 pregnant Swiss mice given intraperitoneal injections of nitrogen mustard (HN/sub 2/) or cyclophosphamide (CP) were evaluated for chromosomal aberrations. Both agents induced dose-dependent increases in the frequency of cells with aberrations observed in embryos from females treated 6 hr before sacrifice. The highest frequencies of cells with aberrations were observed when females were injected 15 or 18 hr before sacrifice on day 12. A teratogenic dose of HN/sub 2/ (1.0 mg/kg) induced significantly higher frequencies of damaged cells than a teratogenic dose of CP (20 mg/kg). Cytogenetic analysis of rodent embryos from pregnant females exposed to xenobiotic agents may be an effective screening test for evaluation of genetic effects induced by transplacental exposure.
- Research Organization:
- Los Alamos National Lab., NM
- OSTI ID:
- 6979808
- Journal Information:
- Teratog., Carcinog., Mutagen.; (United States), Journal Name: Teratog., Carcinog., Mutagen.; (United States) Vol. 3; ISSN TCMUD
- Country of Publication:
- United States
- Language:
- English
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Conference
·
Sun Dec 31 23:00:00 EST 1978
·
OSTI ID:6041133
Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
AMINES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGY
CHROMOSOMAL ABERRATIONS
CYTOLOGY
DOSE-RESPONSE RELATIONSHIPS
DRUGS
EMBRYOS
ENDOXAN
FETAL MEMBRANES
GENETIC EFFECTS
IMMUNOSUPPRESSIVE DRUGS
MAMMALS
MEMBRANES
MICE
MUTATIONS
NITROGEN MUSTARD
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PLACENTA
PRENATAL EXPOSURE
RODENTS
TOXICITY
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
AMINES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGY
CHROMOSOMAL ABERRATIONS
CYTOLOGY
DOSE-RESPONSE RELATIONSHIPS
DRUGS
EMBRYOS
ENDOXAN
FETAL MEMBRANES
GENETIC EFFECTS
IMMUNOSUPPRESSIVE DRUGS
MAMMALS
MEMBRANES
MICE
MUTATIONS
NITROGEN MUSTARD
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
PLACENTA
PRENATAL EXPOSURE
RODENTS
TOXICITY
VERTEBRATES