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Benzene-induced micronuclei formation in mouse fetal liver blood, peripheral blood, and maternal bone marrow cells

Journal Article · · Environmental Management; (United States)
 [1];  [2]; ;  [3]
  1. Univ. of California, Davis (United States) Ministry of Railways, Beijing (China)
  2. Univ. of California, Davis (United States) California Air Resources Board, Sacramento (United States)
  3. Univ. of California, Davis (United States)
+ Show Author Affiliations

The transplacental cytogenetic effects of benzene were studied by using the micronucleus test of polychromatic erythrocytes (PCE) found in both fetal liver and fetal peripheral blood, and were compared with PCE from maternal bone marrow. Timed-pregnant mice received single intraperitoneal doses of benzene on the 14th day of gestation and were sacrificed 21 hours after injection. Benzene elicited a significant increase in the frequency of micronucleated polychromatic erythrocytes (MNPCE) in fetal liver blood cells at doses of 219 to 874 mg/kg, and in fetal peripheral blood cells and maternal bone marrow cells at doses of 437 and 874 mg/kg. The data demonstrate that benzene is a moderate transplacental clastogenic agent, and that the mouse transplacental micronucleus test using fetal liver blood cells is a potentially more sensitive indicator of the genotoxicity of benzene than either fetal peripheral blood or maternal bone marrow cells.

OSTI ID:
5011012
Journal Information:
Environmental Management; (United States), Journal Name: Environmental Management; (United States) Vol. 18:1; ISSN EMNGD; ISSN 0364-152X
Country of Publication:
United States
Language:
English

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Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AROMATICS
BENZENE
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW CELLS
CELL CONSTITUENTS
CELL NUCLEI
CHEMISTRY
CONNECTIVE TISSUE CELLS
CYTOCHEMISTRY
DIGESTIVE SYSTEM
ERYTHROCYTES
FETAL MEMBRANES
FETUSES
GENETIC EFFECTS
GLANDS
HYDROCARBONS
LIVER
MAMMALS
MATERIALS
MEMBRANES
MICE
ORGANIC COMPOUNDS
ORGANS
PLACENTA
PREGNANCY
PRENATAL EXPOSURE
RODENTS
SOMATIC CELLS
VERTEBRATES