Radioimmunoassay in basic and clinical pharmacology

Book · Thu Jan 01 04:00:00 EST 1987

OSTI ID:5293459

Patrono, C; Peskar, B A

The subject of the book is the development, validation and application of radioimmunoassay (RIA) techniques for the measurement of a variety of substances in animal and human body fluids. The book discusses methodological and conceptual issues related to the main classes of mediators of drug action and to drugs themselves, as assayed by this particular analytical technique. A number of introductory chapters provide basic information concerning production and characterization of antibodies, labeling techniques, statistical aspects and validation criteria, insight into problems related to the development and validation of RIA for the newly discovered mediator(s). In the following chapters, the emphasis is placed on the technical details relevant to each class of compounds and on specific aspects of their applications to basic and/or clinical pharmacological studies. New developments in this area, such as monoclonal antibodies and non-radioactive labeling techniques, are also covered.

• OSTI ID: 5293459
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ABSTRACTS
ANTIBODIES
DOCUMENT TYPES
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
LABELLING
LEADING ABSTRACT
MATHEMATICS
MEETINGS
MONOCLONAL ANTIBODIES
PHARMACOLOGY
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
STATISTICS
TESTING
TRACER TECHNIQUES
VALIDATION