Clearance of absorbed selenium by the liver

Conference · Mon Mar 11 00:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5265226

Kato, Tatsuko; Read, R; Rozga, J; Burk, R F ^[1]

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1. Vanderbilt Univ., Nashville, TN (United States)

The liver plays a central role in the metabolism of selenium. It secretes plasma selenoproteins, contains a major fraction of the glutathione peroxidase in the body, and synthesizes excretory metabolites. The role of the liver in processing newly absorbed selenium was studied. Male chow-fed rats were fasted overnight and given 24 ng of selenium as {sup 75}SeO{sub 3}{sup 2{minus}} by stomach tube. Animals were exsanguinated at 15, 30, 45, 60, 90, 120, and 180 min after dosing. Comparison of {sup 75}Se uptake by liver, kidney, heart, muscle, testis, brain, and spleen indicated an earlier uptake by liver than by any other tissue. At 15 min, {sup 75}Se in the portal vein blood was 2.6 times that in the hepatic vein blood. Gel filtration analysis suggested a loose association of {sup 75}Se with protein in plasma at 15 min, but immunoprecipitation indicated it was largely in the form of selenoprotein P after 30 min. End-to-side portacaval shunts (PCS) were constructed in rats and sham-operated animals were used as controls. When {sup 75}SeO{sub 3}{sup 2{minus}} was given to animals with PCS, uptake of {sup 75}Se by liver did not precede uptake by other tissues. Also no gradient was detected across the lungs or kidney. {sup 75}Se content of the kidney was higher in PCS rats than in sham-operated rats. This is consistent with removal of the first-pass effect of the liver facilitating uptake of {sup 75}Se by systemic tissues. These results suggest that the preferential uptake of absorbed selenium by the liver is due both to its position in the portal circulation and to an intrinsic high uptake capacity.

• OSTI ID: 5265226
• Report Number(s): CONF-9104107-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:4; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LIVER
BIOLOGICAL FUNCTIONS
SELENIUM
METABOLISM
CLEARANCE
IMMUNOASSAY
METALLOPROTEINS
PEROXIDASES
SELENIUM 75
TISSUE DISTRIBUTION
TRACER TECHNIQUES
UPTAKE
BETA DECAY RADIOISOTOPES
BIOASSAY
BODY
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
ENZYMES
EVEN-ODD NUCLEI
GLANDS
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
NUCLEI
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
PROTEINS
RADIOISOTOPES
SELENIUM ISOTOPES
SEMIMETALS
560300* - Chemicals Metabolism & Toxicology