Uptake, disposition, and elimination of selenate, selenite and selenomethionine in the fathead minnow (Pimephales promelas)
Selenium-75 selenate and Se/sup 75/ selenite were efficiently absorbed from the gastrointestinal tract of fathead minnows following administration by gavage. Greater than 80% of Se/sup 75/ selenate and Se/sup 75/ selenite were absorbed in 24 hours. Selenium-75 selenate, selenite, and L-selenomethionine were differentially distributed to the body organs of adult fathead minnows. The lowest tissue concentrations of Se/sup 75/ for all compounds were noted in the muscle and the adipose tissue. In general the highest Se/sup 75/ concentrations for the inorganics were noted in the liver and kidneys with the exception of blood Se/sup 75/ selenate during the early time course. In addition to the liver and kidneys, the heart accumulated Se/sup 75/ to the highest concentrations following administration of Se/sup 75/ selenomethionine. The magnitude and rate of Se/sup 75/ accumulation differed significantly for the three compounds during the early stages of uptake and distribution. In contrast the elimination phases for selenate and selenite were nearly identical suggesting a convergence to a common metabolic pool. The partitioning of selenate and selenite into plasma and the cellular fraction of blood differed with both the compound and time following exposure. Selenite proportionally had a greater fraction of Se/sup 75/ associated with the blood cells during the early part of the experiment. Selenium-75 appeared in the bile after administration of each of the three compounds. Although the gonadal accumulation of Se/sup 75/ was small for the three compounds there were indications that redistribution may play an important role in further gonadal accumulation.
- Research Organization:
- Wisconsin Univ., Milwaukee (USA)
- OSTI ID:
- 5150985
- Resource Relation:
- Other Information: Thesis (Ph. D.)
- Country of Publication:
- United States
- Language:
- English
Similar Records
Metabolism in rats of selenium from intrinsically and extrinsically labeled isolated soy protein
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on early life stage development of the fathead minnow (Pimephales promelas)
Related Subjects
SELENIUM COMPOUNDS
INTESTINAL ABSORPTION
TISSUE DISTRIBUTION
ADIPOSE TISSUE
BILE
BLOOD
EXCRETION
FISHES
GONADS
KIDNEYS
LIVER
METABOLISM
METHIONINE
MUSCLES
SELENATES
SELENITES
SELENIUM 75
ABSORPTION
AMINO ACIDS
ANIMAL TISSUES
ANIMALS
AQUATIC ORGANISMS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CLEARANCE
CONNECTIVE TISSUE
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GLANDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
LIPOTROPIC FACTORS
MATERIALS
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
RADIOISOTOPES
SELENIUM ISOTOPES
TISSUES
UPTAKE
VERTEBRATES
550501* - Metabolism- Tracer Techniques