Inhibitory and toxic effects of methylmercuric chloride on the cell cycle of cultured mammalian cells
Technical Report
·
OSTI ID:5246960
The inhibitory and toxic effects of methylmercuric chloride (MeHgCl) on the cell cycle of cultured mammalian cells were investigated in mouse leukemic cells (L5178Y) grown in suspension culture and HeLa M cells grown in monolayer. Population growth, cell division, reproductive integrity and viability were monitored as a function of increasing MeHgCl concentrations during acute and prolonged exposures to the agent.
- Research Organization:
- Rochester Univ., NY (USA). Dept. of Radiation Biology and Biophysics
- DOE Contract Number:
- EY-76-C-02-3490
- OSTI ID:
- 5246960
- Report Number(s):
- UR-3490/LCP-5
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
CELL CULTURES
CELL DIVISION
CELL PROLIFERATION
CHLORIDES
CHLORINE COMPOUNDS
DOSE-RESPONSE RELATIONSHIPS
HALIDES
HALOGEN COMPOUNDS
MERCURY CHLORIDES
MERCURY COMPOUNDS
MERCURY HALIDES
METHYLMERCURY
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
SURVIVAL TIME
TOXICITY
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
CELL CULTURES
CELL DIVISION
CELL PROLIFERATION
CHLORIDES
CHLORINE COMPOUNDS
DOSE-RESPONSE RELATIONSHIPS
HALIDES
HALOGEN COMPOUNDS
MERCURY CHLORIDES
MERCURY COMPOUNDS
MERCURY HALIDES
METHYLMERCURY
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
SURVIVAL TIME
TOXICITY