DNA single-strand breaks of preheated cultured mammalian cells irradiated under nitrogen- and nitrous oxide-saturated conditions. [Gamma radiation]

Journal Article · Thu Sep 01 04:00:00 EDT 1977 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574635· OSTI ID:7075793

Antoku, S

Radiation-induced DNA single-strand breaks were studied using preheated cultured mouse leukemic cells, L5178Y, exposed to /sup 60/Co ..gamma.. rays under N/sub 2/- and N/sub 2/O-saturated conditions. The yields of DNA strand breaks of cells preheated above 50/sup 0/C for 10 min were higher in N/sub 2/O-saturated than N/sub 2/-saturated suspensions, and the maximum N/sub 2/O/N/sub 2/ DNA strand breaks ratio was about 1.6. These results indicated that OH radicals were mainly responsible for the production of DNA strand breaks.

• Research Organization: Hiroshima Univ.
• OSTI ID: 7075793
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 71:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHALCOGENIDES
COBALT 60
COBALT ISOTOPES
CRYOGENIC FLUIDS
DNA
ELECTROMAGNETIC RADIATION
ELEMENTS
FLUIDS
GAMMA RADIATION
HYDROXYL RADICALS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MICE
MINUTES LIVING RADIOISOTOPES
NITROGEN
NITROGEN COMPOUNDS
NITROGEN OXIDES
NITROUS OXIDE
NONMETALS
NUCLEI
NUCLEIC ACIDS
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADICALS
RADIOINDUCTION
RADIOISOTOPES
RADIOSENSITIVITY EFFECTS
RODENTS
STRAND BREAKS
TUMOR CELLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES