Transplantation of human renal cell carcinoma into NMRI nu/nu mice. III. Effect of irradiation on tumor acceptance and tumor growth

Journal Article · Mon Jul 01 04:00:00 EDT 1985 · J. Urol.; (United States)

OSTI ID:5243349

Otto, U; Huland, H; Baisch, H; Kloeppel, G

Irradiation of human renal cell carcinoma before radical tumor nephrectomy resulted in a significantly lower acceptance rate (1 of 7) in nude mice than for nonirradiated tumors (all of 13). The tumor tissue was transplanted into NMRI nu/nu mice immediately after nephrectomy. In this experimental system the authors demonstrated the reduced vitality of human tumor cells after irradiation. In a second series of experiments, 3 morphologically different human renal cell carcinomas were irradiated at various doses after establishment in nude mice. The irradiated tumor tissue was transplanted to the next passage. The morphology, proliferation rate and growth of these tumors were compared with those of nonirradiated controls. Radiation effect was dose dependent in the responding tumor types. The characteristics correlated with radiosensitivity were high proliferation rate (measured by flow cytometry), low cytologic grading and fast growth rate in the nude mice.

• Research Organization: Univ. of Hamburg, Germany, F.R.
• OSTI ID: 5243349
• Journal Information: J. Urol.; (United States), Journal Name: J. Urol.; (United States) Vol. 1; ISSN JOURA
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARCINOMAS
CELL PROLIFERATION
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DOSES
GROWTH
IRRADIATION
MAMMALS
MAN
MICE
NEOPLASMS
PRIMATES
RADIATION DOSES
RADIATION EFFECTS
RADIOSENSITIVITY
RODENTS
TRANSPLANTS
TUMOR CELLS
VERTEBRATES