THE SIGNIFICANCE OF THE TUMOR BED REACTIONS IN THE RADIATION TREATMENT OF MALIGNANT TUMORS

Journal Article · Thu Oct 01 04:00:00 EDT 1959 · Am. J. Roentgenol., Radium Therapy Nuclear Med.

OSTI ID:4222532

Vermund, H

Inbred mice of the Bittner Z and ZBC strains have been used to study the effects of roentgen radiation on transplanted mammary carcinoma and the tumor bed. Irradiation of the tumor bed before transplantation of fresh untreated tumor resulted in retarded tumor growth and delayed onset of palpable tumor nodule. The irradiated animals lived longer than the unirradiated controls but irradiation of the tumor bed alone did not prevent the tumors from growing and all the mice eventually died with large tumors. The dose which caused the optimal effect was 3,000 r. Irradiation after the transplantation with dose levels up to 6,000 r failed to eradicate the tumors when the time interval between the transplantation and the roentgen treatment was more than three weeks. Irradiation within two weeks after the transplantation resulted in permanent inhibition of the tumor growth in close to 70 per cent of the animals. In the remaining 30 per cent, the tumors developed after a long latent period which in some mice extended over more than one year. Tumors growing slowly in an irradiated bed showed similar uptake of radioactive phosphorus into the desoxyribonucleic acid isolated from the tumors as found in the nonirradiated controls. Irradiation of tumor tissue suspended in physiologic saline in vitro tailed to prevent tumor growth upon subsequent transplantation into nonirradiated animals and was less efficient than in vivo roentgen treatments given a short time after the transplantation. In vitro irradiation was slightly more efficient than roentgen treatment of the tumor bed in inhibiting tumor growth. In view of these experimental data, the significance of the tumor bed and the host reactions in radiation treatment of malignant tumors have been discussed. (auth)

• Research Organization: Univ. of Wisconsin, Madison
• NSA Number: NSA-13-020802
• OSTI ID: 4222532
• Journal Information: Am. J. Roentgenol., Radium Therapy Nuclear Med., Journal Name: Am. J. Roentgenol., Radium Therapy Nuclear Med. Vol. Vol: 82
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ABSORPTION
BIOCHEMISTRY
BIOLOGY AND MEDICINE
CANCER
DNA
EFFICIENCY
GLANDS
IRRADIATION
MAMMARY GLANDS
METABOLISM
MICE
NUCLEIC ACIDS
PHOSPHORUS ISOTOPES
QUANTITATIVE ANALYSIS
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
RADIOSENSITIVITY
RADIOTHERAPY
STANDARDS
SURGERY
SURVIVAL TIME
TESTING
TISSUES
TRANSPLANTS
TUMORS
VARIATIONS
VOLUME
X RADIATION