THE DEVELOPMENT OF IMMUNITY TO TRANSPLANTED EHRLICH'S CARCINOMA FOLLOWING INJECTION OF CELLS RADIATED WITH LETHAL DOSES OF X-RAYS
Ehrlich's ascites carcinoma cells, exposed in vitro to a lethal dose of x rays, were administered to mice for the purpose of immunization. Then carcinoma cells not exposed to x rays were subcutaneously inoculated into the legs of the immunized animals. The tumor growin at the injected sites was examined. In mice, pre-treated once (one injection for immunization), the growth of tumor cells was markedly inhibited at 3 weeks after immunization: 30% showed negative transplantation and 30% showed marked delay of development of tumor tissue. In the group pre-treated 3 times the inhibiting effect was genenally lower than in the mice pre-treated once. In the controls, x-irradiated liver tissue was used as material for pre-treatment. No appreciable difference in growth of Ehrlich's carcinoma times the inhibiting effect was generally lower than in the mice pre-treated once. In the controls, x-irradiated liver tissue was used as material for pre-treatment. No appreciable difference in growth of Ehrlich's carcinoma cells between liver-treated and non-treated animals could be observed. (Abstr. Japan. Med., 1: No. 1, 1960)
- Research Organization:
- Kurashiki Central Hospital, Japan
- NSA Number:
- NSA-15-022061
- OSTI ID:
- 4044435
- Journal Information:
- Kurashiki Chuo Byoin Nempo, Journal Name: Kurashiki Chuo Byoin Nempo Vol. Vol: 28
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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