GROWTH OF ASCITES TUMORS IN MICE INJECTED WITH X-IRRADIATED CELLS BY DIFFERENT ROUTES AND IN DIFFERENT DOSES
Studies were made on the growth of Ehrlich's tumor after lethally x irridiited iscitic cells were injected by different routes and in different doses. Susceptible animals. after receiving intriperitoneal inoculations of lethally x- irradiated (10000 r) ascites carcinoma cells. became resistant to later intraperitoneal and subcutaneous injections of viable tumor cells. When x- irradiated cells were given after the subcutaneous implantation of viable tumor cells. rejection of the tumor occurred. X-irradiated cells, when injected after an intriperitoneal transplant. stimulated tumor growth rather than inhibiting it. A slight degree of passive protection was afforded by treatment with serum obtained from immunized mice. Transfer of peritoneal cells from immunized to suceptible mice failed to protect from subsequent tumor grafts. When the intravenous route was used. no distinction was made between the lethally damaged x-irradiated cells and the viable tumor cells. It was postulated that the viable cells were soon damaged by the host and immunity responses from systemic effects occurred. There was evidence that an immune reiction was involved. That the tumor bed was the site of the immune reaction was found in animals with grafts implanted into the brain and into the anterior chamber of the eye. These sites are isolated from the reticuloendothelial system, and rejection did not occur as in animals with subcutaneous implants. (H.H.D.)
- Research Organization:
- Yale Univ., New Haven
- NSA Number:
- NSA-17-005824
- OSTI ID:
- 4739155
- Journal Information:
- Growth (U.S.), Journal Name: Growth (U.S.) Vol. Vol: 25; ISSN GROWA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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