EFFECT OF IN-VITRO X-RAY IRRADIATION ON TRANSPLANTABILITY OF EHRLICH ASCITES CARCINOMA CELLS

Journal Article · Thu Jan 01 04:00:00 EST 1959 · Nippon Igaku Hoshasen Gakkai Zasshi (Japan)

OSTI ID:4045330

Yoshinari, T

When tumor cells are inoculated subcutaneously into the thigh of mice, the growth rate is represented by the difference of the circumferences of the thighs measured before and after transplantation. The experimental relationship between tumor weight and growth was found to be as follows: tumor weight = (tumor growth--13.10) x 1/4.98 g. lf no less than 4.0 x 10/sup 4//0.2 ml of tumor cells were inoculated, all eventually appeared to be positive in transplantation. When the tumor cells were irradiated in vitro before the inoculation, it was observed that the higher the x-ray dose the less the transplantability. in mice injected once with tumor cells damaged by irradiation, the inhibition of the tumor growth was most prominent the third week after the pretreatment. In mice pre-injected three times the transplantability was usually lower than in mice preinjected once. This was probably due to the active immunizations caused by x-ray-damaged tumor cells. (Abstr. Japan Med., 1: No. 2, 1960)

• Research Organization: Osaka Univ.
• NSA Number: NSA-15-022078
• OSTI ID: 4045330
• Journal Information: Nippon Igaku Hoshasen Gakkai Zasshi (Japan), Journal Name: Nippon Igaku Hoshasen Gakkai Zasshi (Japan) Vol. Vol: 19; ISSN NHGZA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
BIOLOGY AND MEDICINE
CANCER
IMMUNITY
MICE
RADIATION DOSES
RADIATION EFFECTS
TRANSPLANTS
X RADIATION