EFFECT OF IN-VITRO X-RAY IRRADIATION ON TRANSPLANTABILITY OF EHRLICH ASCITES CARCINOMA CELLS
When tumor cells are inoculated subcutaneously into the thigh of mice, the growth rate is represented by the difference of the circumferences of the thighs measured before and after transplantation. The experimental relationship between tumor weight and growth was found to be as follows: tumor weight = (tumor growth--13.10) x 1/4.98 g. lf no less than 4.0 x 10/sup 4//0.2 ml of tumor cells were inoculated, all eventually appeared to be positive in transplantation. When the tumor cells were irradiated in vitro before the inoculation, it was observed that the higher the x-ray dose the less the transplantability. in mice injected once with tumor cells damaged by irradiation, the inhibition of the tumor growth was most prominent the third week after the pretreatment. In mice pre-injected three times the transplantability was usually lower than in mice preinjected once. This was probably due to the active immunizations caused by x-ray-damaged tumor cells. (Abstr. Japan Med., 1: No. 2, 1960)
- Research Organization:
- Osaka Univ.
- NSA Number:
- NSA-15-022078
- OSTI ID:
- 4045330
- Journal Information:
- Nippon Igaku Hoshasen Gakkai Zasshi (Japan), Vol. Vol: 19; Other Information: Orig. Receipt Date: 31-DEC-61
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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