Chromosome and biochemcal studies in women occuopationally exposed to lead
Journal Article
·
· Arch. Environ. Health; (United States)
Chromosome and biochemical studies were conducted for 18 healthy females occupationally exposed to lead in the manufacture of electrical storage batteries and in 12 comparable female controls. Biochemical indictors of dose (blood lead) and effect (erythrocyte protoporphyrin, delta-aminolevulinicacid dehydratase activity of red blood cells) were significantly different in the two groups. Cytogenetic studies were performed on lymphocytes cultured for 2 and 3 days with phytohemagglutinin to investigate the possible effect of culture time with respect to yield of chromosome aberrations. The results showed significantly increased rates of metaphases with chromatid and chromosome aberrations-excluding gaps-in the exposed vs. controls at both culture times. The yield of abnormal metaphases was higher in the 3-day than in the 2-day cultures, both in the exposed and controls; the difference was moderately significant for controls, while highly significant for those exposed. These results demonstrate the occurrence of increased numbers of abnormal metaphases also in women occupationally exposed to lead, as previously found in males.
- Research Organization:
- Univ. of Milan, Italy
- OSTI ID:
- 5235687
- Journal Information:
- Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 35:3; ISSN AEHLA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Cytogenetic studies in human populations exposed to gas leak at Bhopal, India
Genetic damage induced by occupationally low mercury exposure
Cytogenetic analyses of mice exposed to dichloromethane
Journal Article
·
Fri Jun 01 00:00:00 EDT 1990
· Environmental Health Perspectives; (USA)
·
OSTI ID:5848689
Genetic damage induced by occupationally low mercury exposure
Journal Article
·
Tue Nov 30 23:00:00 EST 1976
· Environ. Res.; (United States)
·
OSTI ID:7310724
Cytogenetic analyses of mice exposed to dichloromethane
Journal Article
·
Sun Dec 31 23:00:00 EST 1989
· Environmental and Molecular Mutagenesis; (USA)
·
OSTI ID:5848342
Related Subjects
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL DIVISION
CHROMATIDS
CHROMOSOMAL ABERRATIONS
DATA
DATA FORMS
ELEMENTS
ERYTHROCYTES
EXPERIMENTAL DATA
FEMALES
INFORMATION
LEAD
MAMMALS
MAN
MATERIALS
METALS
MITOSIS
MUTATIONS
NUMERICAL DATA
OCCUPATIONAL SAFETY
PRIMATES
SAFETY
TABLES
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL DIVISION
CHROMATIDS
CHROMOSOMAL ABERRATIONS
DATA
DATA FORMS
ELEMENTS
ERYTHROCYTES
EXPERIMENTAL DATA
FEMALES
INFORMATION
LEAD
MAMMALS
MAN
MATERIALS
METALS
MITOSIS
MUTATIONS
NUMERICAL DATA
OCCUPATIONAL SAFETY
PRIMATES
SAFETY
TABLES
VERTEBRATES