Cytogenetic studies in human populations exposed to gas leak at Bhopal, India

Journal Article · Fri Jun 01 04:00:00 EDT 1990 · Environmental Health Perspectives; (USA)

DOI:https://doi.org/10.1289/ehp.9086323· OSTI ID:5848689

Ghosh, B B; Sengupta, S; Roy, A; Maity, S; Ghosh, S; Talukder, G; Sharma, A ^[1]

---

1. Univ. of Calcutta (India)

Frequencies of chromosomal abnormalities, sister chromatid exchanges, and replicative index were assessed following peripheral lymphocyte culture in 129 individuals from Bhopal, India. Of these, 83 persons (40 male and 43 female) had been exposed directly to the methyl isocyanate (MIC) gas after the accident at the Union Carbide plant on December 2 and 3, 1984. The remaining 46 samples were taken from age-matched unexposed persons in the same city. Chromosome aberrations were recorded at first cycle metaphase (M{sub 1}) and sister chromatid exchanges, at second cycle metaphase (M{sub 2}), following standard schedule. The frequency of chromosomal aberrations was, in general, higher in individuals from the exposed populations, with the females showing a higher incidence. Nondisjunction of chromosomes or laggard was rare. The frequencies of sister chromatid exchanges and depression in mitotic and replicative indices could not be related to exposure or sex. The persistence of chromosomal abnormalities in the form of replicating minutes and exchange configurations, even 1,114 days after exposure to the gas, may indicate a residual effect on T-cell precursors.

• OSTI ID: 5848689
• Journal Information: Environmental Health Perspectives; (USA), Journal Name: Environmental Health Perspectives; (USA) Vol. 86; ISSN 0091-6765; ISSN EVHPA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ASIA
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
DEVELOPING COUNTRIES
FEMALES
GENETIC EFFECTS
HUMAN POPULATIONS
INDIA
ISOCYANATES
LEUKOCYTES
LYMPHOCYTES
MALES
MAMMALS
MAN
MATERIALS
MEN
MUTATION FREQUENCY
MUTATIONS
POPULATIONS
PRIMATES
SEX DEPENDENCE
SISTER CHROMATID EXCHANGES
SOMATIC CELLS
VERTEBRATES
WOMEN