Metabolism in the rat of cadmium biocomplexes from edible mussels exposed to /sup 109/CdCl/sub 2/
The metabolism in the rat of /sup 109/Cd biocomplexes present in the tissues of the edible mussel Mytilus galloprovincialis, previously exposed to /sup 109/CdCl/sub 2/, was studied. The tissue distribution and binding of /sup 109/Cd were compared to those caused by an equal dose of /sup 109/Cd as CdCl2 or rat liver Cd-metallothionein. Administration of mussel /sup 109/Cd to rats resulted in an initial accumulation of /sup 109/Cd in the kidneys due to the presence of /sup 109/Cd-metallothionein, which constituted 25% of the /sup 109/Cd in the tissues of the mussels. Other /sup 109/Cd biocomplexes present in the mussel tissues were metabolized in the rat in a way similar to that of inorganic cadmium, i.e., initial accumulation in the liver. These findings indicate that the ingestion of seafood rich in metallothionein may give rise to a faster increase of renal cadmium levels than the consumption of a similar amount of inorganic cadmium.
- Research Organization:
- Commission of the European Communities, Ispra, Italy
- OSTI ID:
- 5229235
- Journal Information:
- Ecotoxicol. Environ. Saf.; (United States), Journal Name: Ecotoxicol. Environ. Saf.; (United States) Vol. 2; ISSN EESAD
- Country of Publication:
- United States
- Language:
- English
Similar Records
Gastrointestinal absorption and organ distribution of oral cadmium chloride and cadmium-metallothionein in mice
Fate of erythrocyte Cd-metallothionein in mice
Related Subjects
560304 -- Chemicals Metabolism & Toxicology-- Invertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AQUATIC ORGANISMS
BETA DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
CADMIUM
CADMIUM 109
CADMIUM ISOTOPES
CONTAMINATION
DIGESTIVE SYSTEM
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
FECES
FOOD CHAINS
GLANDS
INTERMEDIATE MASS NUCLEI
INVERTEBRATES
ISOTOPE APPLICATIONS
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LIVER
MAMMALS
MATERIALS
METABOLIC ACTIVATION
METABOLISM
METALLOPROTEINS
METALLOTHIONEIN
METALS
MOLLUSCS
MUSSELS
NUCLEI
ORGANIC COMPOUNDS
ORGANS
POLLUTION
PROTEINS
RADIOISOTOPES
RATS
RODENTS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
VERTEBRATES
WASTES
WATER POLLUTION
YEARS LIVING RADIOISOTOPES