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Gastrointestinal absorption and organ distribution of oral cadmium chloride and cadmium-metallothionein in mice

Journal Article · · J. Toxicol. Environ. Health; (United States)
; ;

Body retention and tissue distribution of Cd from oral /sup 109/CdCl/sub 2/ and /sup 109/Cd-metallothionein were studied in C57BL/6/ mice given identical doses (60 ..mu..g Cd and 2 ..mu..Ci /sup 109/Cd). Measurement of /sup 109/Cd radioactivity in mice showed identical absorption but differences in tissue distribution of Cd from the two forms. A significantly greater deposition of Cd was observed in the kidney of mice fed Cd-metallothionein than in the CdCl/sub 2/ group where a major portion of Cd was deposited in the liver. Most of the radioactive Cd in the renal and hepatic tissues and in the duodenum was bound to metallothionein 24 h after oral Cd-metallothionein, whereas only 30 and 38% of the cadmium in liver and kidney supernatants, respectively, were bound to metallothionein after oral CdCl/sub 2/. These results suggest that the dietary form of Cd may influence the renal deposition of Cd.

Research Organization:
Univ. of Western Ontario, London, Can.
OSTI ID:
6537867
Journal Information:
J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 4:5-6; ISSN JTEHD
Country of Publication:
United States
Language:
English

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Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CADMIUM
CADMIUM 109
CADMIUM CHLORIDES
CADMIUM COMPOUNDS
CADMIUM HALIDES
CADMIUM ISOTOPES
CHLORIDES
CHLORINE COMPOUNDS
COMPARATIVE EVALUATIONS
DIGESTIVE SYSTEM
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
GLANDS
HALIDES
HALOGEN COMPOUNDS
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
ISOTOPE APPLICATIONS
ISOTOPES
KIDNEYS
LIVER
MAMMALS
METALS
MICE
NUCLEI
ORAL ADMINISTRATION
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPES
RODENTS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES