Biliary excretion of cadmium in rat. II. The role of metallothionein in the hepatobiliary transport of cadmium. [/sup 109/Cd]

Journal Article · Mon Feb 28 23:00:00 EST 1977 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287397709529494· OSTI ID:7259706

Cherian, M G

Intravenous injection of /sup 109/Cd-labeled CdCl/sub 2/ (1 mg/kg) to control rats and rats that had been injected with CdCl/sub 2/ (0.25 mg/kg) 24 hr earlier showed that there was a decrease in the biliary excretion of /sup 109/Cd in the latter group. The 24 hr pretreatment with CdCl/sub 2/ resulted in induced synthesis of metallothionein in rat liver and kidney. The binding of cadmium to liver tissue was increased and the renal accumulation of cadmium was unaltered on cadmium pretreatment. Rat liver metallothionein was isolated from rats injected repeatedly with CdCl/sub 2/. Intravenous injection of cadmium-bound metallothionein gave a different distribution of cadmium in the tissues and biological fluids as compared to injection of CdCl/sub 2/. A major percentage of cadmium was deposited in the kidney with urinary excretion after injection of rat cadmium-metallothionein to control rats. The biliary excretion of cadmium after cadmium-metallothionein injection was minimal. About 90% of cadmium in the kidney cortex and urine could be recovered as cadmium-thionein in sephadex gel filtration, 3 hr after cadmium-thionein injection.

• Research Organization: Univ. of Western Ontario, London
• OSTI ID: 7259706
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 2:4; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
BETA DECAY RADIOISOTOPES
BINDING ENERGY
BIOSYNTHESIS
BODY
CADMIUM 109
CADMIUM CHLORIDES
CADMIUM COMPOUNDS
CADMIUM HALIDES
CADMIUM ISOTOPES
CHLORIDES
CHLORINE COMPOUNDS
DIGESTIVE SYSTEM
ELECTRON CAPTURE RADIOISOTOPES
ENERGY
EVEN-ODD NUCLEI
GLANDS
HALIDES
HALOGEN COMPOUNDS
HETEROCYCLIC COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
KIDNEYS
LIVER
MAMMALS
METABOLISM
NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RODENTS
SYNTHESIS
THIONINE
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES