Biliary excretion of cadmium in rat. V. Effects of structurally related mercaptans on chelation of cadmium from metallothionein

Journal Article · Mon Mar 01 04:00:00 EST 1982 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398209530172· OSTI ID:5210919

Cherian, M G ^[1]; Onosaka, S; Carson, G K; Dean, P A.W.

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1. Univ. of Western Ontario, Canada

Th effects of several mono-, di-, and trithiols in mobilizing Cd from metallothionein were studied in rats 24 h after a single injection of /sup 109/CdCl/sub 2/. BAL (2,3-dimercaptopropanol) and propanetrithiol (1,2,3-trimercaptopropane) were the most effective mercaptans in increasing the biliary excretion of Cd in in situ experiments with a significant decrease in hepatic Cd. Propane-1-thiol was inactive and propanetrithiol was the most toxic of the compounds studied. All the lipophilic compounds with two adjacent sulhydryl groups were effective in increasing the biliary excretion of Cd, but were less effective than BAL and propanetrithiol. The major form of Cd in liver cytosols of rats pretreated with CdCl/sub 2/ and injected with mercaptans was metallothionein. Even though Cd was present mainly as metallothionein in livers of Cd-pretreated rats, the biliary forms of Cd after injection of BAL and propanetrithiol were different. Similar results were obtained when Cd was added in vitro to bile samples collected from control rats that were injected with these chelating agents alone. These results suggested that the Cd-binding ligands present in bile after injection of BAL and propanetrithiol were different from and had a higher molecular weight than the complexes in vitro with Cd and the respective chelating agents.

• OSTI ID: 5210919
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 9:3; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BILE
BILIARY TRACT
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CADMIUM
CADMIUM 109
CADMIUM ISOTOPES
CLEARANCE
COMPLEXES
DIGESTIVE SYSTEM
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
EXCRETION
GLANDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
LIGANDS
LIVER
MAMMALS
MATERIALS
METALLOPROTEINS
METALLOTHIONEIN
METALS
MOLECULAR WEIGHT
NUCLEI
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PROTEINS
RADICALS
RADIOISOTOPES
RATS
RODENTS
SULFHYDRYL RADICALS
THIOLS
TOXICITY
VERTEBRATES
YEARS LIVING RADIOISOTOPES