Biliary excretion of cadmium in rat. IV. Mobilization of cadmium from metallothionein by 2,3-dimercaptopropanol

Journal Article · Sat Mar 01 04:00:00 EST 1980 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398009529859· OSTI ID:5408994

Cherian, M G

Cadmium was preferentially bound to metallothionein in tissues 24 h after CdCl/sub 2/ injection. Of a number of chelating agents examined, only 2,3-dimercapto-1-propanol (BAL) was effective in mobilizing Cd from metallothionein into bile. Structurally similar dithiols such as 1,3-dimercaptopropanol and 2,3-dimercapto-1-propanesulfonic acid were not effective. Diethylenetriamine pentaacetic acid increased only the urinary excretion of Cd. Biliary excretion of Cd increased with increasing dose of BAL, and there was a concurrent decrease in hepatic Cd levels without any increase in renal concentration. BAL was effective even 14 d after Cd injection. The form of Cd excreted in the bile after BAL injection in chronic exposure has not yet been characterized. Initial studies suggested that it was not metallothionein but was a low-molecular-weight Cd complex, probably with BAL.

• Research Organization: Univ. of Western Ontario, London
• OSTI ID: 5408994
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 6:2; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

550200 -- Biochemistry
551000 -- Physiological Systems
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BAL
BILE
BILIARY TRACT
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CADMIUM
CADMIUM COMPLEXES
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
COMPLEXES
DIGESTIVE SYSTEM
DISTRIBUTION
DITHIOLS
DRUGS
ELEMENTS
EXCRETION
GLANDS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
KIDNEYS
KINETICS
LIVER
MAMMALS
MATERIALS
METABOLISM
METALS
MOLECULAR WEIGHT
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RADIOPROTECTIVE SUBSTANCES
RATS
REACTION KINETICS
REAGENTS
RESPONSE MODIFYING FACTORS
RODENTS
THIOLS
TISSUE DISTRIBUTION
URINE
VERTEBRATES
WASTES