Biliary mobilization of cadmium by 2,3-dimercaptopropanol and some related compounds

Journal Article · Tue Jan 01 04:00:00 EST 1980 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398009529832· OSTI ID:5021911

Von Burg, R; Smith, J C

No effective therapeutic agent for mobilizing tissue Cd has been reported to date, but the results presented here demonstrate that 2,3-dimercaptopropanol (BAL), at doses approaching and surpassing the maximum tolerated, can produce a rapid transient enhancement of Cd excretion in the rat. When BAL (75 mg/kg) was administered by a single injection 24 h after a tracer dose of /sup 109/Cd, as much as 32% of the administered Cd appeared in the bile. A correlation between the appearance of radiocadmium and the biliary sulfhydryl concentration was found. There was indirect evidence for a 1:3 Cd-BAL complex in the bile, which may explain the efficacy of higher doses of BAL. A comparative study with some selected dithiol compounds suggests that vicinal sulfhydryl groups on an aliphatic chain are the more effective Cd mobilizing compounds, but BAL was the most effective agent. Although suspending vehicles alone showed no Cd mobilizing ability, the combination of BAL and oil was far superior to any other BAL-vehicle combination used. A spectrophotometric method for the determination of sulfhydryl groups in bile and urine is also presented.

• Research Organization: Univ. of Rochester School of Medicine, NY
• OSTI ID: 5021911
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 6:1; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BAL
BILE
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CADMIUM
CHELATING AGENTS
CLEARANCE
DITHIOLS
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELEMENTS
EXCRETION
MAMMALS
MATERIALS
METALS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIOPROTECTIVE SUBSTANCES
RATS
REAGENTS
RESPONSE MODIFYING FACTORS
RODENTS
SPECTROPHOTOMETRY
THIOLS
URINE
VERTEBRATES
WASTES