Biliary excretion of cadmium in rat. I. Dose-dependent biliary excretion and the form of cadmium in the bile

Journal Article · Tue Mar 01 04:00:00 EST 1977 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287397709529493· OSTI ID:7110272

Cherian, M G; Vostal, J J

Biliary excretion of cadmium was studied in rats after intravenous injection of different doses of cadmium chloride (0.1-2 mg Cd/kg). The rate of bile flow was not affected by cadmium injection and cadmium was excreted into bile during the first 2 hr after injection. The biliary excretion of cadmium increased with increasing dose of CdCl/sub 2/. Cumulative biliary excretion of cadmium for 5 hr was 0.065% of the administered dose for groups injected with 0.1 mg Cd/kg as compared to 16.9% of the administered dose for 2 mg Cd/kg. During the 5 hr experimental period, most of the cadmium in liver cytosol was bound to high-molecular-weight proteins and less than 10% was bound to the metallothionein fraction. The biliary cadmium was recovered as a low-molecular-weight compound (less than 4,000) in experiments with various doses of cadmium and no cadmium was attached to high-molecular-weight proteins or metallothionein in the bile. The low-molecular-weight cadmium complex in bile was partially characterized as Cd-glutathione by thin-layer chromatography and amino acid analysis.

• Research Organization: Univ. of Rochester, NY
• OSTI ID: 7110272
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 2:4; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

550500* -- Metabolism
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BILE
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CADMIUM
CADMIUM CHLORIDES
CADMIUM COMPOUNDS
CADMIUM HALIDES
CHLORIDES
CHLORINE COMPOUNDS
CLEARANCE
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
EXCRETION
GLANDS
HALIDES
HALOGEN COMPOUNDS
LIVER
MAMMALS
METABOLISM
METALS
ORGANS
RATS
RODENTS
VERTEBRATES