Gastrointestinal absorption of cadmium in mice during gestation and lactation

Journal Article · Thu Dec 31 23:00:00 EST 1981 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0041-008X(82)90303-9· OSTI ID:5402490

Bhattacharyya, M H ^[1]; Whelton, B D; Peterson, D P

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1. Argonne National Lab., IL

The effect on cadmium retention of continuous exposure to drinking water containing low levels of cadmium during pregnancy and lactation was studied in mice. Female mice were provided drinking water ad libitum containing /sup 109/CdCl/sub 2/ (0.03 ..mu..Ci /sup 109/Cd/ml, 0.11 ppb total cadmium) throughout either gestation, lactation, or a combined period of pregnancy and lactation. Nonpregnant control mice were exposed to the same cadmium solution for similar time periods. Dams in all three experimental groups retained two to three times cadmium (expressed as percentage of ingested dose) than did nonpregnant controls. The /sup 109/Cd contents of liver, kidney, mammary tissue, and duodenum increased strikingly in all three groups. Increases in kidney and mammary tissue were particularly apparent during lactation, with increases of fivefold for kidney and at least ninefold for mammary tissue, compared to levels in nonpregnant controls. Increases in /sup 109/Cd retention by the duodenum were fivefold during gestation and three- to fourfold during lactation. The kidneys of dams exposed during lactation retained 53% of the whole body /sup 109/Cd, while kidneys of nonpregnant controls retained only 27%. Results indicate that pregnant and lactating mice absorb and subsequently retain substantially more cadmium from their diets than do nonpregnant mice.

• DOE Contract Number: W-31109-ENG-38
• OSTI ID: 5402490
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 66; ISSN TXAPA
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BODY
CADMIUM
CADMIUM 109
CADMIUM ISOTOPES
CHRONIC INTAKE
DIGESTIVE SYSTEM
DRINKING WATER
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
GASTROINTESTINAL TRACT
GLANDS
HYDROGEN COMPOUNDS
INGESTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
INTESTINES
ISOTOPE APPLICATIONS
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LACTATION
LIVER
MAMMALS
MAMMARY GLANDS
METALS
MICE
NUCLEI
ORGANS
OXYGEN COMPOUNDS
PREGNANCY
RADIOISOTOPES
RETENTION
RODENTS
SMALL INTESTINE
TRACER TECHNIQUES
UPTAKE
VERTEBRATES
WATER
YEARS LIVING RADIOISOTOPES