Lactation-induced cadmium-binding proteins
Previously we have demonstrated an increase during midlactation in /sup 109/Cd adsorption and increased retention by the duodenum, kidney, and mammary tissue of mouse dams receiving environmental levels of cadmium//sup 109/Cd via drinking water, with little change in /sup 109/Cd retention in liver and jejunum compared to nonpregnant controls. Results are reported here of a study of cadmium deposition during midlactation as associated with induction of metallothionein (MT). A cadmium/hemoglobin (Cd/Hb) assay and radioimmunoassay for MT which measures heat-stable cadmium binding capacity in tissues was used to determine MT concentrations in fractions of kidney, liver, duodenum, and jejunum from female mice. Both assays demonstrated clear lactation-induced increases in MT concentrations in liver, kidney, and duodenum, with MT concentrations falling rapidly to control levels after weaning. 4 refs., 1 tab.
- Research Organization:
- Argonne National Lab., IL (USA); Duquesne Univ. of the Holy Ghost, Pittsburgh, PA (USA). Dept. of Chemistry; Syracuse Univ., NY (USA). Dept. of Biology
- DOE Contract Number:
- W-31109-ENG-38
- OSTI ID:
- 5712366
- Report Number(s):
- CONF-8706206-2; ON: DE88002617
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
CADMIUM 109
CADMIUM ISOTOPES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ENZYME INDUCTION
EVEN-ODD NUCLEI
GENE REGULATION
IMMUNOASSAY
IMMUNOLOGY
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LACTATION
MAMMALS
METALLOPROTEINS
METALLOTHIONEIN
MICE
NUCLEI
ORGANIC COMPOUNDS
PHYSIOLOGY
PROTEINS
QUANTITY RATIO
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
RADIOISOTOPES
RODENTS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES