Ischemia and infarction in the isolated rabbit heart: a model for the evaluation of Myocardial imaging agents
An isolated-heart preparation has been adapted to permit rapid evaluation of, and imaging by, myocardial tracers. The rabbit heart provided a mass large enough for imaging and serial biopsies. Coronary arteries could be selectively ligated and provided landmarks for epicardial ST segment mapping. Uptake ratios between a tissue sample and normal myocardium (T/N), obtained using Tc-99m glucoheptonate as an infarct-seeker, increased with duration of the ischemic period, which was followed by reflow. After 25 min of occlusion the T/N was 4.5; after 40 min T/N = 6; after 60 min T/N = 8; and after 120 min T/N = 19. This well-controlled adjunct to in vivo studies allows evaluation of myocardial imaging agents without interfering with systemic effects or blood and tissue background. Functional and structural changes can be sequentially measured and correlated with the localization of various radiopharmaceuticals.
- Research Organization:
- New York Hospital, New York
- OSTI ID:
- 5212415
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 21:6; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Detection of myocardial ischemia before infarction, based on accumulation of labeled pyruvate
Augmentation of myocardial ischemia by low level carbon monoxide exposure in dogs
Related Subjects
560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANEMIAS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MODELS
BODY
CARBOXYLIC ACID ESTERS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DATA
DATA FORMS
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DISTRIBUTION
ESTERS
EVALUATION
EXPERIMENTAL DATA
GLUCOHEPTONATE
HEART
HEMIC DISEASES
HOURS LIVING RADIOISOTOPES
IMAGES
IN VITRO
INFORMATION
INTERMEDIATE MASS NUCLEI
ISCHEMIA
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MYOCARDIAL INFARCTION
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
RABBITS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SPATIAL DISTRIBUTION
SYMPTOMS
TABLES
TECHNETIUM 99
TECHNETIUM ISOTOPES
TRACER TECHNIQUES
UPTAKE
VERTEBRATES
YEARS LIVING RADIOISOTOPES