Augmentation of myocardial ischemia by low level carbon monoxide exposure in dogs

Journal Article · Sun Jul 01 04:00:00 EDT 1979 · Arch. Environ. Health; (United States)

DOI:https://doi.org/10.1080/00039896.1979.10667413· OSTI ID:5557062

Becker, L C ^[1]; Haak, Jr, E D

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1. Johns Hopkins Univ., Baltimore, MD

This study was conducted to determine whether low level exposure to carbon monoxide would increase myocardial ischemia associated with acute myocardial infarction. An hour after coronary artery ligation, eleven anesthetized dogs underwent five sequential respiratory exposures to 5000 ppM carbon monoxide, producing mean blood carboxyhemoglobin levels of 4.9% to 17.0%. Ischemia, as indicated by the amount of S-T segment elevation in epicardial electrocardiograms, increased significantly at the lowest carboxyhemoglobin level and increased further with increasing carbon monoxide exposure. These changes occurred in the absence of altered heart rate, blood pressure, left atrial pressure, cardiac output, or blood flow to ischemic myocardium. Flow to non-ischemic myocardium increased with carbon monoxide exposure, the percentage increase being approximately double the increase in carboxyhemoglobin level. Thus, low level exposure to carbon monoxide can significantly augment ischemia in acute myocardial infarction, apparently through a reduction in oxygen supplied to ischemic tissue. The data suggest that hypoxia induced by carbon monoxide exposure is more severe than can be accounted for by a simple reduction in oxygenated hemoglobin.

• OSTI ID: 5557062
• Journal Information: Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 34:4; ISSN AEHLA
• Country of Publication: United States
• Language: English

Related Subjects

551000 -- Physiological Systems
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANEMIAS
ANIMALS
ANOXIA
ARTERIES
BIOLOGICAL EFFECTS
BLOOD FLOW
BLOOD PRESSURE
BLOOD VESSELS
BODY
CARBON COMPOUNDS
CARBON MONOXIDE
CARBON OXIDES
CARBOXYHEMOGLOBIN
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHALCOGENIDES
CORONARIES
CRYOGENIC FLUIDS
DIAGRAMS
DISEASES
DOGS
DYNAMIC FUNCTION STUDIES
ELECTROCARDIOGRAMS
ELEMENTS
FLUIDS
GLOBIN
HEART
HEMIC DISEASES
HEMOGLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INHALATION
INTAKE
ISCHEMIA
MAMMALS
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NONMETALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDES
OXYGEN
OXYGEN COMPOUNDS
PIGMENTS
POLLUTION
PORPHYRINS
PROTEINS
SYMPTOMS
VERTEBRATES