A longitudinal study of growth and growth hormone secretion in children during treatment for acute lymphoblastic leukemia

Journal Article · Tue Jan 01 04:00:00 EST 1991 · Medical and Pediatric Oncology; (United States)

DOI:https://doi.org/10.1002/mpo.2950190409· OSTI ID:5198126

Marky, I; Mellander, L; Lannering, B; Albertsson-Wikland, K ^[1]

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1. Goeteborg Univ. (Sweden)

Diminished growth rate during treatment for acute lymphoblastic leukemia (ALL) is of the multifactorial etiology. Effects on GH secretion have been shown after discontinuation of treatment including prophylactic CNS irradiation. Seventeen children treated for ALL with three different CNS preventive schedules were followed longitudinally with repeated estimations of the spontaneous GH secretion during a 24-month period. No difference was found in GH secretion during this time between patients who had received no radiotherapy and those who had received 18 or 24 Gy as CNS prophylaxis. During dexamethasone treatment the GH secretion was completely suppressed, which can be a mediator for the diminished growth rate during the first 2 years of ALL treatment. We conclude that there is no clinical reason to perform GH analysis within the first 24 months of treatment for ALL.

• OSTI ID: 5198126
• Journal Information: Medical and Pediatric Oncology; (United States), Journal Name: Medical and Pediatric Oncology; (United States) Vol. 19:4; ISSN 0098-1532; ISSN MPOND
• Country of Publication: United States
• Language: English

Related Subjects

550600 -- Medicine
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL HORMONES
AGE GROUPS
ANIMAL GROWTH
ANTIMETABOLITES
CHILDREN
COMBINED THERAPY
CORTICOSTEROIDS
DEXAMETHASONE
DISEASES
DOSES
DRUGS
GLUCOCORTICOIDS
GROWTH
HORMONES
HYDROXY COMPOUNDS
IMMUNE SYSTEM DISEASES
INHIBITION
KETONES
LEUKEMIA
METHOTREXATE
NEOPLASMS
ORGANIC COMPOUNDS
PEPTIDE HORMONES
PITUITARY HORMONES
PREDNISOLONE
PREGNANES
PROTEINS
RADIATION DOSES
SECRETION
STEROID HORMONES
STEROIDS
STH
SURVIVAL CURVES
THERAPY