Studies on the assessment of neurotoxicity in children with acute lymphoblastic leukemia

Journal Article · Sun Mar 01 04:00:00 EST 1987 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19870301)59:5<891::AID-CNCR2820590506>3.0.CO;2-M· OSTI ID:6574050

Muchi, H; Satoh, T; Yamamoto, K; Karube, T; Miyao, M

Central nervous system (CNS) prophylaxis caused a remarkable reduction in the incidence of CNS disease, however there has evolved a growing concern regarding the immediate or late toxicities to the developing CNS. Twenty-eight children with acute lymphoblastic leukemia who survived for more than 2 years were examined for the assessment of neurotoxicity induced by CNS prophylaxis and its treatment. The patients were stratified into three groups: Stratum I, prophylaxis with methotrexate; Stratum II, prophylaxis with cranial irradiation with methotrexate; and Stratum III, with CNS leukemia. Once CNS disease developed the sequelae were frequent and severe, due to the elevated methotrexate levels in the cerebrospinal fluid. CNS prophylaxis with intermediate-dose methotrexate was less toxic to the developing CNS than prophylactic cranial irradiation, especially in children under 5 years of age. Electroencephalograms and evoked potentials are likely to find increasing application in defining the CNS sequelae of acute lymphoblastic leukemia in children and its treatment. Although the sample size was small, the findings delineate specific areas of neurotoxicity.

• Research Organization: Jichi Medical School, Tochigi, Japan
• OSTI ID: 6574050
• Journal Information: Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 5; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

550600 -- Medicine
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
AGE GROUPS
ANTIMETABOLITES
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBROSPINAL FLUID
CHEMOTHERAPY
CHILDREN
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELECTROENCEPHALOGRAPHY
HEMIC DISEASES
IRRADIATION
LEUKEMIA
MATERIALS
MEDICINE
METHOTREXATE
NEOPLASMS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIOLOGY
RADIOTHERAPY
THERAPY