Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

Reduced pulsatile growth hormone secretion in children after therapy for acute lymphoblastic leukemia

Journal Article · · J. Pediatr.; (United States)
; ; ; ;
Basal growth hormone levels were measured every 20 minutes over 24 hours in eight long-term survivors of acute lymphoblastic leukemia and in 13 age- and pubertal stage-matched normal children. Among the patients, the median total basal growth hormone output (AUC) was 43 units, compared with 341 units in the normal control group (P less than 0.001). In the patients, mean pulse amplitude (6.9 ng/ml) and frequency (4.6) over 24 hours also were reduced, compared with the control values (32 ng/ml and 8.5, P less than 0.001 and P less than 0.05, respectively). In addition, normal children secreted more GH at night (median AUC 280) than during the day (113, P less than 0.001). However, this diurnal pattern was absent in three of the patients studied. These data suggest that perturbations of spontaneous pulsatile GH secretion are common after standard therapy for ALL and may be a sensitive means of detecting therapy-related neuroendocrine damage. Blunting of spontaneous pulsatile GH secretion may contribute to the abnormalities in growth seen in children with ALL.
Research Organization:
National Cancer Inst., Bethesda, MD
OSTI ID:
6748591
Journal Information:
J. Pediatr.; (United States), Journal Name: J. Pediatr.; (United States) Vol. 104:2; ISSN JOPDA
Country of Publication:
United States
Language:
English

Similar Records

Neuroendocrine function in survivors of childhood acute lymphocytic leukemia and non-Hodgkins lymphoma: a study of pulsatile growth hormone and gonadotropin secretions
Journal Article · · Am. J. Pediatr. Hematol./Oncol.; (United States) · OSTI ID:6579916
Evaluation of growth hormone release and human growth hormone treatment in children with cranial irradiation-associated short stature
Journal Article · Tue Jan 31 23:00:00 EST 1984 · J. Pediatr.; (United States) · OSTI ID:6723199
Effects of low-dose cranial radiation on growth hormone secretory dynamics and hypothalamic-pituitary function
Journal Article · Mon Aug 01 00:00:00 EDT 1988 · Am. J. Dis. Child.; (United States) · OSTI ID:7184656

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE GROUPS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHILDREN
DELAYED RADIATION EFFECTS
DISEASES
HEMIC DISEASES
HORMONES
LEUKEMIA
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
PEPTIDE HORMONES
PITUITARY HORMONES
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
SECRETION
SIDE EFFECTS
STH
THERAPY