Reduced pulsatile growth hormone secretion in children after therapy for acute lymphoblastic leukemia
Basal growth hormone levels were measured every 20 minutes over 24 hours in eight long-term survivors of acute lymphoblastic leukemia and in 13 age- and pubertal stage-matched normal children. Among the patients, the median total basal growth hormone output (AUC) was 43 units, compared with 341 units in the normal control group (P less than 0.001). In the patients, mean pulse amplitude (6.9 ng/ml) and frequency (4.6) over 24 hours also were reduced, compared with the control values (32 ng/ml and 8.5, P less than 0.001 and P less than 0.05, respectively). In addition, normal children secreted more GH at night (median AUC 280) than during the day (113, P less than 0.001). However, this diurnal pattern was absent in three of the patients studied. These data suggest that perturbations of spontaneous pulsatile GH secretion are common after standard therapy for ALL and may be a sensitive means of detecting therapy-related neuroendocrine damage. Blunting of spontaneous pulsatile GH secretion may contribute to the abnormalities in growth seen in children with ALL.
- Research Organization:
- National Cancer Inst., Bethesda, MD
- OSTI ID:
- 6748591
- Journal Information:
- J. Pediatr.; (United States), Journal Name: J. Pediatr.; (United States) Vol. 104:2; ISSN JOPDA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Evaluation of growth hormone release and human growth hormone treatment in children with cranial irradiation-associated short stature
Effects of low-dose cranial radiation on growth hormone secretory dynamics and hypothalamic-pituitary function
Related Subjects
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE GROUPS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHILDREN
DELAYED RADIATION EFFECTS
DISEASES
HEMIC DISEASES
HORMONES
LEUKEMIA
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
PEPTIDE HORMONES
PITUITARY HORMONES
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
SECRETION
SIDE EFFECTS
STH
THERAPY