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Neuroendocrine function in survivors of childhood acute lymphocytic leukemia and non-Hodgkins lymphoma: a study of pulsatile growth hormone and gonadotropin secretions

Journal Article · · Am. J. Pediatr. Hematol./Oncol.; (United States)
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To assess the neuroendocrine function of long-term survivors of childhood hematologic malignancies, 10 patients who had acute lymphocytic leukemia and two who had non-Hodgkins lymphoma (NHL) (mean age 13.5 +/- 1 year) were studied, who were treated with similar chemotherapeutic regimens with or without 2400 rads of prophylactic cranial irradiation. Pharmacologic growth hormone (GH) stimulation tests and three graded doses of the GH-releasing hormone (1-40-OH-GRH, 0.1, 0.3, and 1 microgram/kg) were administered. Venous sampling for GH and gonadotropin determinations was done at 20-min intervals for 24 h, and a new computerized pulse detection algorithm was used to analyze pulses. All the patients who had neuroendocrine abnormalities were in the cranially irradiated group. Two of the 12 patients were GH deficient, and had abnormal 24-h secretory profiles, blunted GH responses to pharmacologic stimuli, and minimal responses to the three doses of GRH. The pulsatile properties of luteinizing hormone (LH) were normal in 10 of the 12 nongonadally irradiated patients, irrespective of previous cranial irradiation and pubertal stage, when compared with available normative data.

Research Organization:
Univ. of Virginia Medical Center, Charlottesville (USA)
OSTI ID:
6579916
Journal Information:
Am. J. Pediatr. Hematol./Oncol.; (United States), Journal Name: Am. J. Pediatr. Hematol./Oncol.; (United States) Vol. 10:1; ISSN APHOD
Country of Publication:
United States
Language:
English

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Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL GROWTH
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
COMBINED THERAPY
DISEASES
DYNAMIC FUNCTION STUDIES
ENDOCRINE GLANDS
GLANDS
GONADOTROPINS
GROWTH
HEMIC DISEASES
HORMONES
IMMUNE SYSTEM DISEASES
LEUKEMIA
LH
LYMPHOMAS
NEOPLASMS
NERVOUS SYSTEM
ORGANS
PATIENTS
PEPTIDE HORMONES
PITUITARY HORMONES
POST-IRRADIATION EXAMINATION
RADIATION EFFECTS
SECRETION
STH
THERAPY