Evaluation of growth hormone release and human growth hormone treatment in children with cranial irradiation-associated short stature

Journal Article · Wed Feb 01 04:00:00 EST 1984 · J. Pediatr.; (United States)

DOI:https://doi.org/10.1016/S0022-3476(84)80988-9· OSTI ID:6723199

Romshe, C A; Zipf, W B; Miser, A; Miser, J; Sotos, J F; Newton, W A

We studied nine children who had received cranial irradiation for various malignancies and subsequently experienced decreased growth velocity. Their response to standard growth hormone stimulation and release tests were compared with that in seven children with classic GH deficiency and in 24 short normal control subjects. With arginine and L-dopa stimulation, six of nine patients who received radiation had a normal GH response (greater than 7 ng/ml), whereas by design none of the GH deficient and all of the normal children had a positive response. Only two of nine patients had a normal response to insulin hypoglycemia, with no significant differences in the mean maximal response of the radiation and the GH-deficient groups. Pulsatile secretion was not significantly different in the radiation and GH-deficient groups, but was different in the radiation and normal groups. All subjects in the GH-deficient and radiation groups were given human growth hormone for 1 year. Growth velocity increased in all, with no significant difference in the response of the two groups when comparing the z scores for growth velocity of each subject's bone age. We recommend a 6-month trial of hGH in children who have had cranial radiation and are in prolonged remission with a decreased growth velocity, as there is no completely reliable combination of GH stimulation or release tests to determine their response.

• Research Organization: Ohio State University Coll. of Medicine, Columbus
• OSTI ID: 6723199
• Journal Information: J. Pediatr.; (United States), Journal Name: J. Pediatr.; (United States) Vol. 104:2; ISSN JOPDA
• Country of Publication: United States
• Language: English

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550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE GROUPS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CHILDREN
DELAYED RADIATION EFFECTS
DISEASES
GROWTH
HORMONES
INHIBITION
MEDICINE
NEOPLASMS
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SIZE
STH
THERAPY