Cellular responses to neurotoxic compounds of environmental significance

Journal Article · Mon Jan 01 04:00:00 EST 1979 · Neurobehav. Toxicol.; (United States)

OSTI ID:5193170

Spencer, P S

Many neurotoxic chemicals of environmental significance can be conveniently classified according to their cellular site of action in the nervous system. This paper considers neurotoxins which damage the nerve cell body (neuronopathy), its axonal process (axonopathy), or the myelin sheath which segmentally enwraps the myelinated axon (myelinopathy). Each of these three conditions can be reproduced in experimental animals for study of the mechanisms and consequences of neurotoxic damage. Detailed morphological examination of toxic distal axonopathies have stimulated biochemical studies which promise to yield a precise explanation of the molecular basis for this common type of neurotoxic disease. It seems possible that a precise description of the molecular basis for toxic distal axonal degeneration is within sight.

• Research Organization: Albert Einstein College of Medicine, Bronx, NY (USA)
• OSTI ID: 5193170
• Journal Information: Neurobehav. Toxicol.; (United States), Journal Name: Neurobehav. Toxicol.; (United States); ISSN NETOD
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANTIGENS
BIOLOGICAL MODELS
ENVIRONMENTAL EXPOSURE
MATERIALS
NERVE CELLS
NERVOUS SYSTEM
PATHOLOGICAL CHANGES
SENSITIVITY
SOMATIC CELLS
TOXIC MATERIALS
TOXICITY
TOXINS
XENOBIOTICS