Hexacarbon neurotoxicity
Journal Article
·
· Neurobehav. Toxicol. Teratol.; (United States)
OSTI ID:5025163
The neurotoxicity of hexacarbon solvents has become apparent only recently, but an extensive literature has already developed as a result of the clinical and epidemiological implications of the human disease, and the advantages of small animal models of hexacarbon neurotoxicity in investigation of experimental neuropathies. This review selectively summarizes the literature, focusing on clinical manifestations and pathological alterations in the peripheral nerves. The clinical manifestations are dominated by a distal, symmetrical, and sensorimotor polyneuropathy. Pathological changes include distal axonal degeneration and formation of neurofilament-filled axonal swellings in early or moderately severe exposure. A late manifestation in severely affected experimental animals is recurrent demyelination and remyelination.
- Research Organization:
- Johns Hopkins Univ. School of Medicine, Baltimore, MD
- OSTI ID:
- 5025163
- Journal Information:
- Neurobehav. Toxicol. Teratol.; (United States), Journal Name: Neurobehav. Toxicol. Teratol.; (United States) Vol. 3:4; ISSN NTOTD
- Country of Publication:
- United States
- Language:
- English
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560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
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AGE GROUPS
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560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADOLESCENTS
AGE GROUPS
ALKANES
ANIMALS
BEHAVIOR
CENTRAL NERVOUS SYSTEM
DOCUMENT TYPES
GUINEA PIGS
HEXANE
HYDROCARBONS
KETONES
MAMMALS
NERVES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
PATHOLOGY
REVIEWS
RODENTS
SOLVENTS
TOXICITY
VERTEBRATES