Public control of environmental health hazards (clinical and experimental studies of distal axonopathy--a frequent form of brain and nerve damage produced by environmental chemical hazards)

Journal Article · Mon Jan 01 04:00:00 EST 1979 · Ann. N.Y. Acad. Sci.; (United States)

DOI:https://doi.org/10.1111/j.1749-6632.1979.tb15331.x· OSTI ID:6447423

Schaumburg, H H; Spencer, P S

Clinical and pathological studies of the peripheral and central nervous system degeneration (distal dying-back axonopathy) in humans and experimental animals produced by acrylamide monomer and certain hydrocarbon compounds are summarized. The human distal axonopathies include: many of the naturally occurring, genetically determined system disorders/ certain nutritional disorders/ uremic neuropathy/ the neuropathies associated with some malignancies/ and the toxic neuropathies induced by industrial chemicals. The irreversible, subclinical, and clinical effects of distal axonopathies on the human central nervous system are examined. A morphological rationale for previously enigmatic clinical phenomena in the human toxic neuropathies is presented. Neuropathology is potentially useful in the screening of chemicals for neurotoxicity. (7 photos, 24 references)

• Research Organization: Albert Einstein College of Medicine
• OSTI ID: 6447423
• Journal Information: Ann. N.Y. Acad. Sci.; (United States), Journal Name: Ann. N.Y. Acad. Sci.; (United States) Vol. 329; ISSN ANYAA
• Country of Publication: United States
• Language: English

Related Subjects

550900 -- Pathology
570000* -- Health & Safety
59 BASIC BIOLOGICAL SCIENCES
99 GENERAL AND MISCELLANEOUS
ACRYLAMIDE
AMIDES
ANIMALS
CENTRAL NERVOUS SYSTEM
CHEMICAL EFFLUENTS
HYDROCARBONS
INDUSTRY
MAMMALS
MAN
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOLOGICAL CHANGES
PRIMATES
PUBLIC HEALTH
TOXICITY
VERTEBRATES