Propylene oxide causes central-peripheral distal axonopathy in rats

Journal Article · Thu Sep 01 00:00:00 EDT 1988 · Arch. Environ. Health; (United States)

DOI:https://doi.org/10.1080/00039896.1988.9934948· OSTI ID:6597354

Ohnishi, A; Yamamoto, T; Murai, Y; Hayashida, Y; Hori, H; Tanaka, I

In Wistar rats subjected daily to a 6-hr exposure of propylene oxide (PO) at a concentration of 1,500 ppm (5 times a wk for 7 wk), ataxia developed in the hindlegs. Myelinated fibers in hindleg nerves and in the fasciculus gracilis showed axonal degeneration, sparing the nerve cell body of the first sacral dorsal root ganglion and myelinated fibers of the first sacral dorsal and ventral roots. These pathologic findings are compatible with central-peripheral distal axonopathy. This is apparently the first animal model of PO neuropathy to be verified histologically.

• Research Organization: Univ. of Occupational and Environmental Health, Kitakyushu (Japan)
• OSTI ID: 6597354
• Journal Information: Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 43:5; ISSN AEHLA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ALKENES
ANIMALS
BIOLOGICAL MODELS
HYDROCARBONS
MAMMALS
NERVES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
POLLUTION
PROPYLENE
RATS
RODENTS
TOXICITY
VERTEBRATES