Alteration in frequencies of different classes of chromosome aberrations throughout the first cell cycle following X irradiation
Journal Article
·
· Radiat. Res.; (United States)
The frequencies of different classes of aberrations induced by 250 rad of X rays following pulse-labeling with tritiated thymidine were scored in successive time samples of metaphase cells over one cell cycle in a cell line with a very simple karyotype. The experimental conditions precluded the possibility that cells were in their second division following irradiation. It was found that chromosome-type aberrations were common in cells apparently in early S at the time of irradiation, that is, in labeled metaphases found at later collection times, and gradually declined in frequency at earlier collection times. The most frequent class of aberrations in early S cells was sister unions. Sister unions were also found in cells irradiated in G/sub 1/. The data suggest that those classes of aberrations usually described as of the isochromatid type are more probably of the chromosome type, or are chromosome-chromatid interchanges.
- Research Organization:
- Cancer Inst., Melbourne, Australia
- OSTI ID:
- 5176820
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 81:2; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200 -- Biochemistry
550400 -- Genetics
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL CULTURES
CELL CYCLE
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
ELECTROMAGNETIC RADIATION
HETEROCYCLIC COMPOUNDS
IONIZING RADIATIONS
KARYOTYPE
LABELLED COMPOUNDS
MUTATION FREQUENCY
MUTATIONS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIMIDINES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RIBOSIDES
THYMIDINE
TIME DEPENDENCE
TRITIUM COMPOUNDS
X RADIATION
550400 -- Genetics
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL CULTURES
CELL CYCLE
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
ELECTROMAGNETIC RADIATION
HETEROCYCLIC COMPOUNDS
IONIZING RADIATIONS
KARYOTYPE
LABELLED COMPOUNDS
MUTATION FREQUENCY
MUTATIONS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIMIDINES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RIBOSIDES
THYMIDINE
TIME DEPENDENCE
TRITIUM COMPOUNDS
X RADIATION