Dose-yield relationships for individual types of chromosome aberrations in cells irradiated in early S

Journal Article · Thu Jan 01 04:00:00 EST 1981 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575438· OSTI ID:6578260

Moore, R C

The dose-yield relationships for individual classes of chromosome aberrations were measured for cells irradiated in early S after release from thymidine block. It was found that the yield for asymmetrical chromosome exchanges as a function of dose was quadratic, whereas that for sister unions was linear. These data cannot be reconciled with the Chadwick-Leenhouts hypothesis, which predicts that the initial lesion leading to aberration formation is always of a mixed one-hit, two-hit type, resulting in DNA double-stranded breaks. The data support the classical theory of aberration formation that initial lesions are of a one-hit type and that exchanges are of the two-hit type, involving two initial lesions, each of the one-hit type.

• Research Organization: Cancer Inst., Melbourne, Australia
• OSTI ID: 6578260
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 85:1; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

550400 -- Genetics
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CELL CYCLE
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
COMPARATIVE EVALUATIONS
DICENTRIC CHROMOSOMES
DNA
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
HETEROCYCLIC COMPOUNDS
IONIZING RADIATIONS
KARYOTYPE
MUTATIONS
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIMIDINES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RIBOSIDES
SISTER CHROMATID EXCHANGES
STRAND BREAKS
THYMIDINE
X RADIATION