Catecholamine differential modulation of PMA and superantigen stimulated lymphocytes

Conference · Fri Mar 15 04:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5172708

Downs, M O; Johnson, H M ^[1]

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1. Univ. of Florida, Gainesville (United States)

Neurotransmitters have been demonstrated to be important modulators of immune regulation. The authors have previously demonstrated that the catecholamine agonists isoproterenol (Iso), epinephrine (Epi), and norepinephrine (Nor) are potent inhibitors of IFN{gamma} production by phorbol myristate acetate (PMA) stimulated T-cell lymphoma cell line (L12-R4) with the order of potency being Iso > Epi > Nor. Herein, they describe a differential effect of catecholamine influence on staphylococcal enterotoxin A (SEA) stimulated murine splenic cell cultures. Norepinephrine and to a lesser extent Epi can cause a biphasic modulation of IFN{gamma} production. Inhibition of INF{gamma}was seen in the micromolar range while augmentation occurred at the nanomolar range. In light of previous work, these data suggest that {beta}-adrenergic agonist stimulation of antigen presenting cells (APC) may be immunosuppressive while {alpha}-agonist stimulation immunopotentiating. Further, APC may play a central role in determining the net outcome of catecholamine stimulation by being able to mediate signals from both pathways. This response may represent a peripheral neurotransmitter mediated mechanism for fine tuning' immunoreactivity.

• OSTI ID: 5172708
• Report Number(s): CONF-9104107--
• Conference Information: Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (United States) Journal Volume: 5:5
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
AMINES
ANIMAL CELLS
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL PATHWAYS
BIOSYNTHESIS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARCINOGENS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CATECHOLAMINES
CELL CULTURES
CELL PROLIFERATION
CONNECTIVE TISSUE CELLS
DRUGS
ESTERS
GROWTH FACTORS
HORMONES
HYDROXY COMPOUNDS
IMMUNE REACTIONS
INTERFERON
KINETICS
LEUKOCYTES
LYMPHOCYTES
LYMPHOKINES
MAMMALS
MATERIALS
MICE
MITOGENS
NEUROREGULATORS
NORADRENALINE
ORGANIC COMPOUNDS
PHENOLS
PHORBOL ESTERS
POLYPHENOLS
PROTEINS
REACTION KINETICS
RODENTS
SOMATIC CELLS
SPLEEN CELLS
SYMPATHOMIMETICS
SYNTHESIS
VERTEBRATES