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Differential plasma catecholamine and neuropeptide Y responses to acute stress in rats

Journal Article · · Life Sci.; (United States)
; ;
Neuropeptide Y (NPY) is a vasoconstrictor present in the sympatho-adrenomedullary system and may be co-released with norepinephrine (NE) and epinephrine (EPI) during sympathetic activation. The authors studied plasma NPY-immunoreactivity (-ir, radioimmunoassay) and catecholamine (radioenzymatic) responses during two acute stress paradigms that differ in character, intensity, and duration. The intermittent stress of footshock evoked intensity-dependent immediate increments in plasma NE and EPI, and a delayed NPY-ir response. Prolonged immobilization caused greater increases in plasma NE and EPI levels and no changes in plasma NPY-ir until the end of the stress session. Plasma NPY-ir responses correlated with those of NE but not with EPI suggesting a sympathetic origin for the release of the peptide. Relatively greater NPY-ir responses to footshock than to immobilization may be consistent with a preferential release of the peptide by a bursting but not continuous mode of sympathetic activation. However, it may also be due to a differential activation of the sympathetic nerves and adrenal medulla by these two stress situations.
Research Organization:
Georgetown Univ., Washington, DC (USA)
OSTI ID:
5298900
Journal Information:
Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 42:17; ISSN LIFSA
Country of Publication:
United States
Language:
English

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Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ADRENALINE
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL STRESS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CATECHOLAMINES
DRUGS
HORMONES
HYDROXY COMPOUNDS
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
MAMMALS
NERVOUS SYSTEM
NEUROREGULATORS
NORADRENALINE
ORGANIC COMPOUNDS
PEPTIDES
PHENOLS
POLYPHENOLS
PROTEINS
RADIOASSAY
RADIOENZYMATIC ASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
RATS
RODENTS
SECRETION
STEROID HORMONES
SYMPATHOMIMETICS
TRACER TECHNIQUES
VASOCONSTRICTORS
VERTEBRATES