Pulmonary function in juvenile and young adult rats exposed to low-level NO sub 2 with diurnal spikes
Journal Article
·
· Journal of Toxicology and Environmental Health; (USA)
OSTI ID:5154687
Pulmonary function was examined for juvenile and young adult Fischer 344 rats that were continuously exposed to NO{sub 2} (0.5, 1.0, or 2.0 ppm) for up to 6 wk. The exposure included twice daily 1-h spikes equal to 3 times the baseline concentration. This spike-to-baseline ratio was chosen to simulate morning and evening urban rush-hour conditions. Juvenile rats were examined after 3 and 6 wk of NO{sub 2} exposure, whereas young adult rats were examined after 1-, 3-, and 6-wk intervals. Lung volumes, compliance, and efficiency of ventilation distribution were evaluated. Lung volumes increased in the juvenile rats after 3- and 6-wk exposures to 1.0 and 2.0 ppm NO{sub 2}, but were unchanged in young adult rats. Lung compliance increased in juvenile rats exposed to 1.0 or 2.0 ppm NO{sub 2} for 3 wk. However, it was unchanged in juvenile rats exposed for 6 wk or in young adult rats exposed for 1 or 3 wk. Compliance decreased in young adult rats exposed to 2.0 ppm NO{sub 2} for 6 wk and was correlated to an overall thickening of alveolar interstitium and septal tissue. However, the observed changes in pulmonary function were marginal and reversible, since lung-function measurements were not different from controls after a 3-wk recovery period.
- OSTI ID:
- 5154687
- Journal Information:
- Journal of Toxicology and Environmental Health; (USA), Journal Name: Journal of Toxicology and Environmental Health; (USA) Vol. 23:2; ISSN JTEHD; ISSN 0098-4108
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE GROUPS
ANIMALS
BIOLOGICAL FUNCTIONS
BODY
CHALCOGENIDES
COMPARATIVE EVALUATIONS
DAILY VARIATIONS
FUNCTIONS
LUNGS
MAMMALS
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
ORGANS
OXIDES
OXYGEN COMPOUNDS
RATS
RESPIRATORY SYSTEM
RODENTS
TOXICITY
VARIATIONS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE GROUPS
ANIMALS
BIOLOGICAL FUNCTIONS
BODY
CHALCOGENIDES
COMPARATIVE EVALUATIONS
DAILY VARIATIONS
FUNCTIONS
LUNGS
MAMMALS
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
ORGANS
OXIDES
OXYGEN COMPOUNDS
RATS
RESPIRATORY SYSTEM
RODENTS
TOXICITY
VARIATIONS
VERTEBRATES