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Evaluating the toxicity of urban patterns of oxidant gases. 2. Effects in mice from chronic exposure to nitrogen dioxide

Technical Report ·
OSTI ID:5413983
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This study evaluates the influence of a chronic exposure to an urban pattern of NO/sub 2/ (continuous baseline exposure of 0.2 ppm on which were superimposed two 1-hr spikes of 0.8 ppm NO/sub 2/, 5 days/wk) as compared to the baseline exposure to determine the contribution of the spikes to toxicity. Mice were exposed for up to 52 wk with interim examinations. Multivariate analysis of variance revealed a statistically significant treatment effect on infectivity (p=0.05) and pulmonary function (p=0.03) parameters. Infectivity mortality of mice in the spiked exposure regimen was significantly greater than that in either the NO/sub 2/-background exposed mice or in control mice. Four of the pulmonary-function variables exhibited the greatest differences among the treatment groups: end expiratory volume, vital capacity, respiratory system compliance, and multiple-breath nitrogen washout. Results from the pulmonary function analyses indicate that the spiked exposures to 0.8 ppm NO/sub 2/ may have induced a subtle lesion. The chronic study results indicate that the presence of spikes of NO/sub 2/ is contributing significantly to effects on antibacterial lung defenses and pulmonary function of mice.
Research Organization:
Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
OSTI ID:
5413983
Report Number(s):
PB-88-139969/XAB; EPA-600/J-87/097
Country of Publication:
United States
Language:
English

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Related Subjects

500200* -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
560300 -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMALS
BIOASSAY
BIOLOGICAL EFFECTS
CHALCOGENIDES
CHRONIC EXPOSURE
LABORATORY ANIMALS
MAMMALS
MICE
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
OXIDES
OXYGEN COMPOUNDS
POLLUTION
RODENTS
URBAN AREAS
VERTEBRATES