Evaluating the toxicity of urban patterns of oxidant gases. II. Effects in mice from chronic exposure to nitrogen dioxide

Journal Article · Thu Jan 01 04:00:00 EST 1987 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398709531005· OSTI ID:6496577

Miller, F J; Graham, J A; Raub, J A; Illing, J W; Menache, M G; House, D E; Gardner, D E

The study reported herein evaluates the influence of a chronic exposure to an urban pattern of NO/sub 2/ (continuous baseline exposure of 0.2 ppm, on which were superimposed two 1-h spikes of 0.8 ppm NO/sub 2/, 5 d/wk) as compared to the baseline exposure to determine the contribution of the spikes to toxicity. Mice were exposed for up to 52 wk with interim examinations. Multivariate analysis of variance revealed a statistically significant treatment effect on infectivity (p = 0.05) and pulmonary function (p = 0.03) parameters. Infectivity mortality of mice in the spiked exposure regimen was significantly greater than that in either the NO/sub 2/-background-exposed mice or in control mice. Four of the pulmonary function variables exhibited the greatest differences among the treatment groups: end expiratory volume, vital capacity, respiratory-system compliance, and multiple-breath nitrogen washout. Results from the pulmonary-function analyses indicate that the spiked exposures to 0.8 ppm NO/sub 2/ may have induced a subtle lesion. The chronic study results indicate that the presence of spikes of NO/sub 2/ is contributing significantly to effects on antibacterial lung defenses and pulmonary function of mice.

• Research Organization: Environmental Protection Agency, Research Triangle Park, NC
• OSTI ID: 6496577
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 1-2; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMALS
BIOLOGICAL FUNCTIONS
BIOLOGICAL MODELS
BODY
CHALCOGENIDES
CHRONIC EXPOSURE
FUNCTIONS
LUNGS
MAMMALS
MATHEMATICS
MICE
MULTIVARIATE ANALYSIS
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
ORGANS
OXIDES
OXYGEN COMPOUNDS
POLLUTION
RESPIRATORY SYSTEM
RODENTS
SENSITIVITY
STATISTICS
TOXICITY
URBAN AREAS
VERTEBRATES