Pulmonary function in juvenile and young adult rats exposed to low-level NO/sub 2/ with diurnal spikes

Technical Report · Fri Jan 01 04:00:00 EST 1988

OSTI ID:6922509

Stevens, M A; Menache, M G; Crapo, J D; Miller, F J; Graham, J A

Pulmonary function was examined in juvenile and young adult Fischer-344 rats continuously exposed to NO/sub 2/ (0.5, 1.0 or 2.0 ppm) for up to 6 weeks with twice daily 1 hr spikes equal to 3X the baseline concentration. The spike-to-baseline ratio was chosen to simulate morning and evening urban rush-hour conditions. Juvenile rats were examined after 3 and 6 weeks of NO/sub 2/ exposures, while young adult rats were examined after 1, 3, and 6 week intervals. Lung volumes, compliance, and efficiency of ventilation were evaluated. Lung volumes increased in the juvenile rats after 3 and 6 week exposures to 1.0 and 2.0 ppm, but were unchanged in young adult rats. Lung compliance increased in juvenile rats exposed to 1.0 or 2.0 ppm for 3 weeks, however, was unchanged in juvenile rats exposed for 6 weeks, as well as in the young adult rats exposed for 1 and 3 weeks. Compliance decreased in young adult rats exposed to 2.0 ppm for 6 weeks, and was correlated to an overall thickening of alveolar interstitium and spetal tissues.

• Research Organization: Northrop Services, Inc., Research Triangle Park, NC (USA)
• OSTI ID: 6922509
• Report Number(s): PB-88-219720/XAB
• Country of Publication: United States
• Language: English

Related Subjects

550900 -- Pathology
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
CHALCOGENIDES
INHALATION
INTAKE
MAMMALS
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
OXIDES
OXYGEN COMPOUNDS
RATS
RESPIRATORY SYSTEM
RODENTS
VENTILATION
VERTEBRATES