Distributions of /sup 137/Cs, /sup 201/T1, /sup 203/Hg, /sup 203/Pb and /sup 57/Co in a rat hepatoma model. Comparison with /sup 67/Ga

Journal Article · Sun Jan 01 04:00:00 EST 1978 · Invest. Radiol.; (United States)

DOI:https://doi.org/10.1097/00004424-197801000-00009· OSTI ID:5150715

Chauncey, Jr, D M; Hagan, P L; Halpern, S E; McKegney, M L

The distribution of carrier-free /sup 203/Pb-acetate, /sup 203/HgCl/sub 2/, /sup 57/Cocl/sub 2/, /sup 137/CsCl and /sup 201/TlCl was investigated in rats bearing thigh-implanted Morris 7777 hepatomas. Viable and nonviable tumor tissue was collected in order to determine the relative affinities of the radiopharmaceutical for these tissues. The animals were sacrificed at 4, 24, 48, 72 and 96 hrs following intravenous injection. Washout of the radioisotope from the viable tumor tissue was rapid, the maximum concentration being reached on or before 4 hrs following injection. In contrast, residual activity within the nonviable tumor tissue decreased much more slowly and in some cases even increased with time. Viable tumor-to-muscle and nonvialbe tumor-to-muscle ratios for /sup 203/Pb, /sup 203/Hg and /sup 57/Co were comparable to the analogous ratios reported for /sup 67/Ga. However, none of these isotopes approached /sup 67/Ga as a potential tumor imaging agent because the large ratios were the result of low muscle uptake rather than high tumor uptake. Blood clearance of /sup 67/Ga was faster than any of the five cations, while viable and nonviable tumor affinity for /sup 67/Ga was greater than for any of the radiopharmaceuticals studied.

• Research Organization: Veterans Administration Hospital, San Diego, CA
• OSTI ID: 5150715
• Journal Information: Invest. Radiol.; (United States), Journal Name: Invest. Radiol.; (United States) Vol. 13:1; ISSN INVRA
• Country of Publication: United States
• Language: English

Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BLOOD-PLASMA CLEARANCE
BODY
CESIUM 137
CESIUM ISOTOPES
CLEARANCE
COBALT 57
COBALT ISOTOPES
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
EXPERIMENTAL NEOPLASMS
GALLIUM 67
GALLIUM ISOTOPES
GLANDS
HEAVY NUCLEI
HEPATOMAS
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEAD 203
LEAD ISOTOPES
LIVER
MAMMALS
MERCURY 203
MERCURY ISOTOPES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RODENTS
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
THALLIUM 201
THALLIUM ISOTOPES
TISSUE DISTRIBUTION
VERTEBRATES
YEARS LIVING RADIOISOTOPES