Comparison of tumor uptake and kinetics of different radiopharmaceuticals under experimental conditions
Journal Article
·
· Acta Radiol., Ther., Phys., Biol., v. 11, no. 6, pp. 566-576
Using the transplantable Yoshida sarcoma in the rat, radiation activity concentrations were determined in tumor, blood, and muscle at various times for / sup 67/Ga-citrate, /sup 99m/Tc-pertechnetate, /sup 75/Seselenite, /sup 203/HgCl/ sub 2/, /sup 197/Hg-H-albumin, /sup 197/Hg-BMHP, /sup 20 3/Hg-chlormerodrin, and / sup 131/I-H-albumin. Gallium-67 exhibited the highest tumor uptake and the most favorable tumor/blood ratio. For some radiopharmaceuticals the extent of tumor uptake correlated with their biologic half life in the blood. There is some evidence that the model might be comparable with the human. (auth)
- Research Organization:
- Univ., Goettingen, Ger.
- NSA Number:
- NSA-29-010491
- OSTI ID:
- 4391601
- Journal Information:
- Acta Radiol., Ther., Phys., Biol., v. 11, no. 6, pp. 566-576, Journal Name: Acta Radiol., Ther., Phys., Biol., v. 11, no. 6, pp. 566-576; ISSN ATHBA
- Country of Publication:
- Sweden
- Language:
- English
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