Technetium-99m stannous citrate brain-tumor uptake in mice: concise communication
Journal Article
·
· J. Nucl. Med.; (United States)
OSTI ID:5236883
The pharmacodynamics of technetium-99m stannous citrate were studied in Yale--Swiss mice bearing a sarcoma-like transplantable brain tumor, and the renal kinetics were determined in normal mice. Using a rating system based on tumor uptake and tumor-to-brain, tumor-to-blood, and tumor-to-skin ratios, the data obtained with this compound were compared with similar data obtained previously in the same model with Tc-99m Fe-(ascorbic acid), Tc-99m Fe-(ascorbic acid)-DTPA, Tc-99m Sn-DTPA, (/sup 99m/Tc) pertechnetate, and (/sup 99m/Tc) pertechnetate with perchlorate predose. Technetium-99m stannous citrate does not appear to achieve tumor localization by a mode different from these other Tc-99m-labeled compounds, nor does it show any potential advantage as a scanning agent in this tumor model.
- Research Organization:
- Univ. of Texas System Cancer Center, Houston
- OSTI ID:
- 5236883
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 18:9; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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Tue Dec 31 23:00:00 EST 1985
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OSTI ID:6654406
Related Subjects
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
BRAIN
CENTRAL NERVOUS SYSTEM
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
MAMMALS
MICE
NEOPLASMS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RODENTS
SCINTISCANNING
SKIN
TECHNETIUM 99
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
BRAIN
CENTRAL NERVOUS SYSTEM
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
MAMMALS
MICE
NEOPLASMS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RODENTS
SCINTISCANNING
SKIN
TECHNETIUM 99
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES