Tissue distribution of /sup 203/Pb--acetate: comparison with /sup 67/Ga--citrate as an abscess-localizing agent. [Rats]

Journal Article · Wed Sep 01 04:00:00 EDT 1976 · J. Nucl. Med.; (United States)

OSTI ID:7337458

Taylor, A Jr; Hagan, P; Alazaki, N; Hall, P

Since /sup 203/Pb-acetate accumulates in necrotic tumor tissue, the possibility was raised that it might also accumulate in other necrotic tissue such as abscess. We first studied the tissue distribution and excretion of /sup 203/Pb-acetate in control rats at 4, 24, 48, 72, and 96 hr. An enterohepatic circulation for lead is suggested. We then compared the uptakes of /sup 203/Pb-acetate and /sup 67/Ga-citrate in experimental abscesses in rats. The mean gallium accumulation in the abscess was 10 times that of lead at 24 hr and 12 times that of lead at 72 hr. The abscess-to-tissue ratios were greater for gallium for every tissue examined, although the abscessed areas were clearly visualized by scanning at 24 and 72 hr with both agents. With the exception of blood, abscess-to-tissue ratios for /sup 67/Ga at 24 hr were higher than or equal to those at 72 hr. However, the /sup 67/Ga ratios for the inflamed tissue surrounding the abscess to muscle and blood were higher at 72 hr than at 24 hr, which suggests that inflammation without abscess might be better identified by gallium scanning at 72 hr.

• Research Organization: Veterans Administration Hospital, San Diego, CA
• OSTI ID: 7337458
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 17:9; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSCESSES
ACETATES
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BIOLOGICAL MATERIALS
BLOOD
BODY FLUIDS
CARBOXYLIC ACID SALTS
CITRATES
CLEARANCE
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
EXCRETION
GALLIUM 67
GALLIUM ISOTOPES
HEAVY NUCLEI
INFLAMMATION
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LEAD 203
LEAD ISOTOPES
MAMMALS
MUSCLES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
PATHOLOGICAL CHANGES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RATS
RODENTS
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
TISSUE DISTRIBUTION
VERTEBRATES