Tumor model studies of /sup 131/I-tetracycline and other compounds

Journal Article · Thu Apr 01 04:00:00 EST 1976 · J. Nucl. Med.; (United States)

OSTI ID:7193082

Chauncey, D M; Halpern, S E; Hagan, P L; Alazraki, N P

Iodine-131-tetracycline (/sup 131/I-TET) was prepared by allowing tetracycline hydrochloride to react with radioiodide in acidic methanol (labeling efficiency greater than 85 percent). This preparation was found to be stable at --4/sup 0/C for at least 72 hr. Some minimal in vivo breakdown did occur. The /sup 131/I-TET, /sup 67/Ga, and several /sup 99m/Tc compounds were studied in a rat hepatoma model. The incorporation of the radiopharmaceuticals into the tumor occurred rapidly, with peak levels at 0.5 and 24 hr after injection for /sup 131/I-TET and /sup 67/Ga, respectively. The clearance of the radiopharmaceutical from nonviable tumor was slower than for viable tumor, and by 72 hr after injection the greatest concentration of radioactivity appeared in the nonviable fraction. All normal tissues showed faster clearance than did tumor tissue, regardless of viability. Decreasing the quantity of /sup 131/I-TET injected increased the percent of uptake in the nonviable tumor tissue but had no effect on the viable tumor uptake. Of the /sup 99m/Tc compounds studied, the phosphates developed the highest tumor-to-background ratios. Unfortunately these ratios were not as high as those achieved for /sup 67/Ga or /sup 131/I-TET.

• Research Organization: Veterans Administration Hospital, San Diego, CA
• OSTI ID: 7193082
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 17:4; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTIBIOTICS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GALLIUM 67
GALLIUM ISOTOPES
GLANDS
HEPATOMAS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIVER
MAMMALS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OXYGEN COMPOUNDS
PHOSPHATES
PHOSPHORUS COMPOUNDS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RATS
RODENTS
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
TETRACYCLINES
VERTEBRATES
YEARS LIVING RADIOISOTOPES