Selective uptake of /sup 99m/Tc complexes and $sup 67$Ga in acutely infarcted myocardium
The suitability of various radiopharmaceuticals (/sup 99m/Tc- tetracycline analogs, /sup 99m/Tc-glucoheptonate, /sup 99m/Tc-diphosphonate, and $sup 67$Ga-citrate) for use in imaging acute myocardial infarction was assessed by determining their biologic distributions in experimentally infarcted dogs. The highest infarct-to-normal myocardial concentration ratio was found with /sup 99m/Tc-diphosphonate (27.9:1); the highest infarct-to-liver ratio was also found with /sup 99m/Tc-diphosphonate (15.9:1). The infarct-to-bone ratio, however, was 0.4:1 with /sup 99m/Tc-diphosphonate. There was an excellent positive linear correlation between blood-flow reduction and uptake of the radiopharmaceutical after a threshold reduction in blood flow with /sup 99m/Tc- glucoheptonate and / sup 99m/Tc-tetracycline. Technetium-99m-tetracycline accumulated only in infarcted tissue while /sup 99m/Tc-diphosphonate was increased in both ischemic and infarcted tissue. Thus, /sup 99m/Tc-diphosphonate has characteristics best suited for scintigraphic imaging. Since /sup 99m/Tc-tetracycline accumulates only in infarcted tissue, however, this tracer more accurately defines the size of an acute infarction. (auth)
- Research Organization:
- Harvard Medical School, Boston
- NSA Number:
- NSA-33-007707
- OSTI ID:
- 4158327
- Journal Information:
- J. Nucl. Med., v. 16, no. 11, pp. 975-979, Journal Name: J. Nucl. Med., v. 16, no. 11, pp. 975-979; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Evaluation of radiopharmaceuticals for the detection of acute myocardial infarction in man. [/sup 99m/Tc]
Effect of coronary blood flow and site of injection on Tc-99m PPi detection of early canine myocardial infarcts