Accumulation of /sup 99m/Tc-glucoheptonate in acutely infarcted myocardium

Journal Article · Wed Oct 01 00:00:00 EDT 1975 · J. Nucl. Med., v. 16, no. 10, pp. 875-878

OSTI ID:4191014

Rossman, D J; Strauss, H W; Siegel, M E; Pitt, B

The distribution of /sup 99m/Tc-glucoheptonate in normal mice and its accumulation in acutely infarcted myocardium were studied in animals. Rapid blood clearance and low concentration of the tracer in normal myocardium were found in tissue distribution studies performed in mice. Experimental myocardial infarction was performed in nine dogs. Four hours after the intravenous injection of /sup 99m/Tc-glucoheptonate the uptake ratio of the myocardial infarcted area to normal myocardium was 20:1; to blood, 9:1; and to lung, 6:1. The greatest concentration of radiopharmaceutical in the infarcted tissue was noted in areas that had 20 to 10 percent of normal perfusion. Regions of infarction were clearly defined by external gamma scintigraphy. Clinical investigation of this tracer in humans appears warranted. (auth)

• Research Organization: Johns Hopkins Medical Inst., Baltimore
• NSA Number: NSA-33-001037
• OSTI ID: 4191014
• Journal Information: J. Nucl. Med., v. 16, no. 10, pp. 875-878, Journal Name: J. Nucl. Med., v. 16, no. 10, pp. 875-878; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

*MYOCARDIAL INFARCTION-- DIAGNOSTIC TECHNIQUES
*MYOCARDIUM-- SCINTISCANNING
*RADIOPHARMACEUTICALS-- TISSUE DISTRIBUTION
*TECHNETIUM 99-- DIAGNOSTIC TECHNIQUES
550501* --Biomedical Sciences
Basic Studies--Metabolism-- Tracer Techniques
DOGS
ISOMERIC NUCLEI
MICE
N48830* --Life Sciences--New Tracer Techniques--Other
RADIONUCLIDE ADMINISTRATION
RETENTION
TESTING